Hyperinsulinemia promotes aberrant histone acetylation in triple-negative breast cancer

BACKGROUND: Hyperinsulinemia, the presence of excess insulin relative to glucose in the blood, is considered to be a poor prognostic indicator for patients with triple-negative breast cancer (TNBC). mTOR, a downstream effector of insulin, enhances mitochondrial biogenesis and activity, thereby incre...

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Detalhes bibliográficos
Publicado no:Epigenetics Chromatin
Main Authors: Senapati, Parijat, Kato, Hiroyuki, Lee, Michael, Leung, Amy, Thai, Christine, Sanchez, Angelica, Gallagher, Emily J., LeRoith, Derek, Seewaldt, Victoria L., Ann, David K., Schones, Dustin E.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6636093/
https://ncbi.nlm.nih.gov/pubmed/31315653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13072-019-0290-9
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