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HnRNPA1 interacts with G-quadruplex in the TRA2B promoter and stimulates its transcription in human colon cancer cells

The human TRA2B gene consists of 10 exons and 9 introns and produces 5 splice isoforms (TRA2β1 to TRA2β5). TRA2B exon 2 encodes multiple premature termination codons. TRA2β1 lacks exon 2 and is translated into a functional transformer 2β (Tra2β) protein, whereas TRA2β4 contains 10 exons and works as...

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Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Nishikawa, Tatsuya, Kuwano, Yuki, Takahara, Yumiko, Nishida, Kensei, Rokutan, Kazuhito
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2019
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6635519/
https://ncbi.nlm.nih.gov/pubmed/31311954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-46659-x
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