STAT1 Gain-of-Function Mutations Cause High Total STAT1 Levels With Normal Dephosphorylation

Signal transducer and activator of transcription (STAT1)1 gain of function (GOF) pathogenic variants have been associated with increased levels of phosphorylated STAT1 and STAT1-dependent cellular responses. Delayed dephosphorylation was proposed as the underlying mechanism leading to the characteri...

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Detalles Bibliográficos
Publicado en:Front Immunol
Main Authors: Zimmerman, Ofer, Olbrich, Peter, Freeman, Alexandra F., Rosen, Lindsey B., Uzel, Gulbu, Zerbe, Christa S., Rosenzweig, Sergio D., Kuehn, Hye Sun, Holmes, Kevin L., Stephany, David, Ding, Li, Sampaio, Elizabeth P., Hsu, Amy P., Holland, Steven M.
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2019
Assuntos:
Immunology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6635460/
https://ncbi.nlm.nih.gov/pubmed/31354696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.01433
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