The solution structure of the human IgG2 subclass is distinct from those for human IgG1 and IgG4 providing an explanation for their discrete functions

Human IgG2 antibody displays distinct therapeutically-useful properties compared with the IgG1, IgG3, and IgG4 antibody subclasses. IgG2 is the second most abundant IgG subclass, being able to bind human FcγRII/FcγRIII but not to FcγRI or complement C1q. Structural information on IgG2 is limited by...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Hui, Gar Kay, Gardener, Antoni D., Begum, Halima, Eldrid, Charles, Thalassinos, Konstantinos, Gor, Jayesh, Perkins, Stephen J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2019
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6635440/
https://ncbi.nlm.nih.gov/pubmed/31088911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.007134
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