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A role for ABCB1 in prognosis, invasion and drug resistance in ependymoma

Three of the hallmarks of poor prognosis in paediatric ependymoma are drug resistance, local invasion and recurrence. We hypothesised that these hallmarks were due to the presence of a sub-population of cancer stem cells expressing the multi-drug efflux transporter ABCB1. ABCB1 gene expression was o...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Sabnis, Durgagauri H., Storer, Lisa C. D., Liu, Jo-Fen, Jackson, Hannah K., Kilday, J. P., Grundy, Richard G., Kerr, Ian D., Coyle, Beth
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6635358/
https://ncbi.nlm.nih.gov/pubmed/31311995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-46700-z
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