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Enhancing Natural Killer and CD8(+) T Cell-Mediated Anticancer Cytotoxicity and Proliferation of CD8(+) T Cells with HLA-E Monospecific Monoclonal Antibodies
Cytotoxic NK/CD8(+) T cells interact with MHC-I ligands on tumor cells through either activating or inhibiting receptors. One of the inhibitory receptors is CD94/NKG2A. The NK/CD8(+) T cell cytotoxic capability is lost when tumor-associated human leukocyte antigen, HLA-E, binds the CD94/NKG2A recept...
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| Publicado no: | Monoclon Antib Immunodiagn Immunother |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Mary Ann Liebert, Inc., publishers
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6634170/ https://ncbi.nlm.nih.gov/pubmed/31009335 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/mab.2018.0043 |
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