Transgenic Mice with Chronic NGF Deprivation and Alzheimer's Disease-Like Pathology Display Hippocampal Region-Specific Impairments in Short- and Long-Term Plasticities

The etiology of Alzheimer's disease (AD) remains elusive. The “amyloid” hypothesis states that toxic action of accumulated β-amyloid peptide (Aβ) on synaptic function causes AD cognitive decline. This hypothesis is supported by analysis of familial AD (FAD)-based transgenic mouse models, where...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Houeland, Gry, Romani, Armando, Marchetti, Cristina, Amato, Gianluca, Capsoni, Simona, Cattaneo, Antonino, Marie, Hélène
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2010
Assuntos:
Brief Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6633528/
https://ncbi.nlm.nih.gov/pubmed/20881126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0457-10.2010
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