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The Anticonvulsant Response to Valproate in Kindled Rats Is Correlated with Its Effect on Neuronal Firing in the Substantia Nigra Pars Reticulata: A New Mechanism of Pharmacoresistance

Resistance to antiepileptic drugs (AEDs) is a major problem in epilepsy treatment. However, mechanisms of resistance are only incompletely understood. We have recently shown that repeated administration of the AED phenytoin allows selecting resistant and responsive rats from the amygdala kindling mo...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Töllner, Kathrin, Wolf, Saskia, Löscher, Wolfgang, Gernert, Manuela
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6633222/
https://ncbi.nlm.nih.gov/pubmed/22072692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2506-11.2011
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