Increased Hippocampal Default Mode Synchronization during Rest in Middle-Aged and Elderly APOE ε4 Carriers: Relationships with Memory Performance

The apolipoprotein (APOE) ε4 allele is a strong genetic risk factor for Alzheimer's disease (AD). Intrinsic fluctuations of brain activity measured by fMRI during rest may be sensitive to AD-related neuropathology. In particular, functional connectivity of the default-mode network (DMN) has gai...

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Veröffentlicht in:J Neurosci
Hauptverfasser: Westlye, Erling T., Lundervold, Arvid, Rootwelt, Helge, Lundervold, Astri J., Westlye, Lars T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2011
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6633142/
https://ncbi.nlm.nih.gov/pubmed/21613490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1230-11.2011
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