Methylation Regulates Alpha-Synuclein Expression and Is Decreased in Parkinson's Disease Patients' Brains

Alpha-synuclein (SNCA) is a major risk gene for Parkinson's disease (PD), and increased SNCA gene dosage results in a parkinsonian syndrome in affected families. We found that methylation of human SNCA intron 1 decreased gene expression, while inhibition of DNA methylation activated SNCA expres...

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Bibliografiske detaljer
Udgivet i:J Neurosci
Main Authors: Jowaed, Ahmad, Schmitt, Ina, Kaut, Oliver, Wüllner, Ullrich
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2010
Fag:
Brief Communications
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6632710/
https://ncbi.nlm.nih.gov/pubmed/20445061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.6119-09.2010
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