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Caffeine citrate enhanced cisplatin antitumor effects in osteosarcoma and fibrosarcoma in vitro and in vivo

BACKGROUND: While multiagent chemotherapy has dramatically improved the prognosis of sarcoma, the novel chemotherapeutics have hardly developed over the past 30 years. Caffeine can induce apoptosis, delays in cell cycle progression and can enhance the cytocidal effects of anti-cancer agents. Citrate...

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Detalhes bibliográficos
Publicado no:BMC Cancer
Main Authors: Abe, Kensaku, Yamamoto, Norio, Hayashi, Katsuhiro, Takeuchi, Akihiko, Tsuchiya, Hiroyuki
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6631922/
https://ncbi.nlm.nih.gov/pubmed/31307409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-019-5891-y
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