Animal to human translation: a systematic scoping review of reported concordance rates

BACKGROUND: Drug development is currently hampered by high attrition rates; many developed treatments fail during clinical testing. Part of the attrition may be due to low animal-to-human translational success rates; so-called “translational failure”. As far as we know, no systematic overview of pub...

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Dettagli Bibliografici
Pubblicato in:J Transl Med
Autori principali: Leenaars, Cathalijn H. C., Kouwenaar, Carien, Stafleu, Frans R., Bleich, André, Ritskes-Hoitinga, Merel, De Vries, Rob B. M., Meijboom, Franck L. B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2019
Soggetti:
Review
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6631915/
https://ncbi.nlm.nih.gov/pubmed/31307492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-019-1976-2
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