Aberrant Calcium Signaling in Astrocytes Inhibits Neuronal Excitability in a Human Down Syndrome Stem Cell Model

Down syndrome (DS) is a genetic disorder that causes cognitive impairment. The staggering effects associated with an extra copy of human chromosome 21 (HSA21) complicates mechanistic understanding of DS pathophysiology. We examined the neuron-astrocyte interplay in a fully recapitulated HSA21 trisom...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Mizuno, Grace O., Wang, Yinxue, Shi, Guilai, Wang, Yizhi, Sun, Junqing, Papadopoulos, Stelios, Broussard, Gerard J., Unger, Elizabeth K., Deng, Wenbin, Weick, Jason, Bhattacharyya, Anita, Chen, Chao-Yin, Yu, Guoqiang, Looger, Loren L., Tian, Lin
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6631348/
https://ncbi.nlm.nih.gov/pubmed/29996097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.06.033
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados