Nasal Administration and Plasma Pharmacokinetics of Parathyroid Hormone Peptide PTH 1-34 for the Treatment of Osteoporosis

Nasal delivery of large peptides such as parathyroid 1-34 (PTH 1-34) can benefit from a permeation enhancer to promote absorption across the nasal mucosa into the bloodstream. Previously, we have published an encouraging bioavailability (78%), relative to subcutaneous injection in a small animal pre...

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Detalhes bibliográficos
Publicado no:Pharmaceutics
Main Authors: Pearson, Richard G., Masud, Tahir, Blackshaw, Elaine, Naylor, Andrew, Hinchcliffe, Michael, Jeffery, Kirk, Jordan, Faron, Shabir-Ahmed, Anjumn, King, Gareth, Lewis, Andrew L., Illum, Lisbeth, Perkins, Alan C.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6631119/
https://ncbi.nlm.nih.gov/pubmed/31181662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics11060265
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