3-Vinylazetidin-2-Ones: Synthesis, Antiproliferative and Tubulin Destabilizing Activity in MCF-7 and MDA-MB-231 Breast Cancer Cells

Microtubule-targeted drugs are essential chemotherapeutic agents for various types of cancer. A series of 3-vinyl-β-lactams (2-azetidinones) were designed, synthesized and evaluated as potential tubulin polymerization inhibitors, and for their antiproliferative effects in breast cancer cells. These...

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Detalhes bibliográficos
Publicado no:Pharmaceuticals (Basel)
Main Authors: Wang, Shu, Malebari, Azizah M., Greene, Thomas F., O’Boyle, Niamh M., Fayne, Darren, Nathwani, Seema M., Twamley, Brendan, McCabe, Thomas, Keely, Niall O., Zisterer, Daniela M., Meegan, Mary J.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6630832/
https://ncbi.nlm.nih.gov/pubmed/30979033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ph12020056
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