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Increased Immunogenicity of Full-Length Protein Antigens through Sortase-Mediated Coupling on the PapMV Vaccine Platform

Background: Flexuous rod-shape nanoparticles—made of the coat protein of papaya mosaic virus (PapMV)—provide a promising vaccine platform for the presentation of viral antigens to immune cells. The PapMV nanoparticles can be combined with viral antigens or covalently linked to them. The coupling to...

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Detalhes bibliográficos
Publicado no:Vaccines (Basel)
Main Authors: Laliberté-Gagné, Marie-Ève, Bolduc, Marilène, Thérien, Ariane, Garneau, Caroline, Casault, Philippe, Savard, Pierre, Estaquier, Jérome, Leclerc, Denis
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6630801/
https://ncbi.nlm.nih.gov/pubmed/31212772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/vaccines7020049
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