Histamine-Induced Conjunctivitis and Breakdown of Blood–Tear Barrier in Dogs: A Model for Ocular Pharmacology and Therapeutics

Conjunctival inflammation disturbs the blood–tear barrier and thus affects the tear film stability and composition. We aimed to develop a non-invasive and reliable method to induce conjunctivitis in dogs, a large animal model for translational work on ocular surface disease in humans. Six beagle dog...

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Bibliographic Details
Published in:Front Pharmacol
Main Authors: Sebbag, Lionel, Allbaugh, Rachel A., Weaver, Amanda, Seo, Yeon-Jung, Mochel, Jonathan P.
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2019
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6629934/
https://ncbi.nlm.nih.gov/pubmed/31354477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.00752
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