Heat-killed Mycobacterium tuberculosis prime-boost vaccination induces myeloid-derived suppressor cells with spleen dendritic cell–killing capability

Tuberculosis patients and mice infected with live Mycobacterium tuberculosis accumulate high numbers of myeloid-derived suppressor cells (MDSCs). Here, we hypothesized that dead M. tuberculosis vaccines also may induce MDSCs that could impair the efficacy of vaccination. We found that repeated injec...

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Publicado en:JCI Insight
Main Authors: Ribechini, Eliana, Eckert, Ina, Beilhack, Andreas, Du Plessis, Nelita, Walzl, Gerhard, Schleicher, Ulrike, Ritter, Uwe, Lutz, Manfred B.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2019
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6629241/
https://ncbi.nlm.nih.gov/pubmed/31162143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.128664
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