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Down syndrome mouse models have an abnormal enteric nervous system

Children with trisomy 21 (Down syndrome [DS]) have a 130-fold increased incidence of Hirschsprung disease (HSCR), a developmental defect in which the enteric nervous system (ENS) is missing from the distal bowel (i.e., distal bowel is aganglionic). Treatment for HSCR is surgical resection of agangli...

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Vydáno v:JCI Insight
Hlavní autoři: Schill, Ellen M., Wright, Christina M., Jamil, Alisha, LaCombe, Jonathan M., Roper, Randall J., Heuckeroth, Robert O.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6629165/
https://ncbi.nlm.nih.gov/pubmed/30998504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.124510
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