TRIOBP-5 sculpts stereocilia rootlets and stiffens supporting cells enabling hearing

TRIOBP remodels the cytoskeleton by forming unusually dense F-actin bundles and is implicated in human cancer, schizophrenia, and deafness. Mutations ablating human and mouse TRIOBP-4 and TRIOBP-5 isoforms are associated with profound deafness, as inner ear mechanosensory hair cells degenerate after...

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Publicado en:JCI Insight
Autores principales: Katsuno, Tatsuya, Belyantseva, Inna A., Cartagena-Rivera, Alexander X., Ohta, Keisuke, Crump, Shawn M., Petralia, Ronald S., Ono, Kazuya, Tona, Risa, Imtiaz, Ayesha, Rehman, Atteeq, Kiyonari, Hiroshi, Kaneko, Mari, Wang, Ya-Xian, Abe, Takaya, Ikeya, Makoto, Fenollar-Ferrer, Cristina, Riordan, Gavin P., Wilson, Elisabeth A., Fitzgerald, Tracy S., Segawa, Kohei, Omori, Koichi, Ito, Juichi, Frolenkov, Gregory I., Friedman, Thomas B., Kitajiri, Shin-ichiro
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2019
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6629139/
https://ncbi.nlm.nih.gov/pubmed/31217345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.128561
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