Histone H2B monoubiquitination regulates heart development via epigenetic control of cilia motility

Genomic analyses of patients with congenital heart disease (CHD) have identified significant contribution from mutations affecting cilia genes and chromatin remodeling genes; however, the mechanism(s) connecting chromatin remodeling to CHD is unknown. Histone H2B monoubiquitination (H2Bub1) is catal...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Robson, Andrew, Makova, Svetlana Z., Barish, Syndi, Zaidi, Samir, Mehta, Sameet, Drozd, Jeffrey, Jin, Sheng Chih, Gelb, Bruce D., Seidman, Christine E., Chung, Wendy K., Lifton, Richard P., Khokha, Mustafa K., Brueckner, Martina
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2019
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6628794/
https://ncbi.nlm.nih.gov/pubmed/31235600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1808341116
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