The energetic basis for hydroxyapatite mineralization by amelogenin variants provides insights into the origin of amelogenesis imperfecta

Small variations in the primary amino acid sequence of extracellular matrix proteins can have profound effects on the biomineralization of hard tissues. For example, a change in one amino acid within the amelogenin protein can lead to drastic changes in enamel phenotype, resulting in amelogenesis im...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Tao, Jinhui, Shin, Yongsoon, Jayasinha, Rajith, Buchko, Garry W., Burton, Sarah D., Dohnalkova, Alice C., Wang, Zheming, Shaw, Wendy J., Tarasevich, Barbara J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2019
Schlagworte:
Physical Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6628643/
https://ncbi.nlm.nih.gov/pubmed/31239344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1815654116
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