Synthesis and Preliminary Biological Evaluation of Two Fluoroolefin Analogs of Largazole Inspired by the Structural Similarity of the Side Chain Unit in Psammaplin A

Largazole, isolated from a marine Cyanobacterium of the genus Symploca, is a potent and selective Class I HDAC (histone deacetylation enzymes) inhibitor. This natural 16-membered macrocyclic depsipeptide features an interesting side chain unit, namely 3-hydroxy-7-mercaptohept-4-enoic acid, which occ...

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Vydáno v:Mar Drugs
Hlavní autoři: Zhang, Bingbing, Shan, Guangsheng, Zheng, Yinying, Yu, Xiaolin, Ruan, Zhu-Wei, Li, Yang, Lei, Xinsheng
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2019
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6628159/
https://ncbi.nlm.nih.gov/pubmed/31163697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/md17060333
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