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Nucleolar and Ribosomal Dysfunction—A Common Pathomechanism in Childhood Progerias?
The nucleolus organizes around the sites of transcription by RNA polymerase I (RNA Pol I). rDNA transcription by this enzyme is the key step of ribosome biogenesis and most of the assembly and maturation processes of the ribosome occur co-transcriptionally. Therefore, disturbances in rRNA transcript...
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| Publicado no: | Cells |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
MDPI
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6627804/ https://ncbi.nlm.nih.gov/pubmed/31167386 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells8060534 |
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