Redesigning Arenicin-1, an Antimicrobial Peptide from the Marine Polychaeta Arenicola marina, by Strand Rearrangement or Branching, Substitution of Specific Residues, and Backbone Linearization or Cyclization

Arenicin-1, a β-sheet antimicrobial peptide isolated from the marine polychaeta Arenicola marina coelomocytes, has a potent, broad-spectrum microbicidal activity and also shows significant toxicity towards mammalian cells. Several variants were rationally designed to elucidate the role of structural...

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Detalhes bibliográficos
Publicado no:Mar Drugs
Main Authors: Orlov, Dmitriy S., Shamova, Olga V., Eliseev, Igor E., Zharkova, Maria S., Chakchir, Oleg B., Antcheva, Nikolinka, Zachariev, Sotir, Panteleev, Pavel V., Kokryakov, Vladimir N., Ovchinnikova, Tatiana V., Tossi, Alessandro
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6627698/
https://ncbi.nlm.nih.gov/pubmed/31234579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/md17060376
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