Glutamate Stimulation Dysregulates AMPA Receptors-Induced Signal Transduction Pathway in Leber’s Inherited Optic Neuropathy Patient-Specific hiPSC-Derived Retinal Ganglion Cells

The mitochondrial genetic disorder, Leber’s hereditary optic neuropathy (LHON), is caused by a mutation in MT-ND4 gene, encoding NADH dehydrogenase subunit 4. It leads to the progressive death of retinal ganglion cells (RGCs) and causes visual impairment or even blindness. However, the precise mecha...

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Pubblicato in:Cells
Autori principali: Yang, Yi-Ping, Nguyen, Phan Nguyen Nhi, Lin, Tai-Chi, Yarmishyn, Aliaksandr A., Chen, Wun-Syuan, Hwang, De-Kuang, Chiou, Guang-Yuh, Lin, Tzu-Wei, Chien, Chian-Shiu, Tsai, Ching-Yao, Chiou, Shih-Hwa, Chen, Shih-Jen, Peng, Chi-Hsien, Hsu, Chih-Chien
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6627514/
https://ncbi.nlm.nih.gov/pubmed/31234430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells8060625
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