Targeting Cyclooxygenase-2 in Pheochromocytoma and Paraganglioma: Focus on Genetic Background

Cyclooxygenase 2 (COX-2) is a key enzyme of the tumorigenesis-inflammation interface and can be induced by hypoxia. A pseudohypoxic transcriptional signature characterizes pheochromocytomas and paragangliomas (PPGLs) of the cluster I, mainly represented by tumors with mutations in von Hippel–Lindau...

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Detalhes bibliográficos
Publicado no:Cancers (Basel)
Main Authors: Ullrich, Martin, Richter, Susan, Seifert, Verena, Hauser, Sandra, Calsina, Bruna, Martínez-Montes, Ángel M., ter Laak, Marjolein, Ziegler, Christian G., Timmers, Henri, Eisenhofer, Graeme, Robledo, Mercedes, Pietzsch, Jens
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6627450/
https://ncbi.nlm.nih.gov/pubmed/31142060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11060743
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