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The transcription factor LEF1 promotes tumorigenicity and activates the TGF-β signaling pathway in esophageal squamous cell carcinoma

BACKGROUND: Esophageal squamous cell carcinoma (ESCC) is the most difficult subtype of esophageal cancer to treat due to the paucity of effective targeted therapy. ESCC is believed to arise from cancer stem cells (CSCs) that contribute to metastasis and chemoresistance. Despite advances in diagnosis...

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Bibliografski detalji
Izdano u:J Exp Clin Cancer Res
Glavni autori: Zhao, Yue, Zhu, Ji, Shi, Bowen, Wang, Xinyu, Lu, Qijue, Li, Chunguang, Chen, Hezhong
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2019
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6625065/
https://ncbi.nlm.nih.gov/pubmed/31296250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-019-1296-7
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