Caricamento...

Pharmacokinetic and pharmacodynamic modelling for renal function dependent urinary glucose excretion effect of ipragliflozin, a selective sodium–glucose cotransporter 2 inhibitor, both in healthy subjects and patients with type 2 diabetes mellitus

AIMS: To provide a model‐based prediction of individual urinary glucose excretion (UGE) effect of ipragliflozin, we constructed a pharmacokinetic/pharmacodynamic (PK/PD) model and a population PK model using pooled data of clinical studies. METHODS: A PK/PD model for the change from baseline in UGE...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Br J Clin Pharmacol
Autori principali: Saito, Masako, Kaibara, Atsunori, Kadokura, Takeshi, Toyoshima, Junko, Yoshida, Satoshi, Kazuta, Kenichi, Ueyama, Eiji
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2019
Soggetti:
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6624389/
https://ncbi.nlm.nih.gov/pubmed/31026084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13972
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !