Lamin A molecular compression and sliding as mechanisms behind nucleoskeleton elasticity

Lamin A is a nuclear intermediate filament protein critical for nuclear architecture and mechanics and mutated in a wide range of human diseases. Yet little is known about the molecular architecture of lamins and mechanisms of their assembly. Here we use SILAC cross-linking mass spectrometry to dete...

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Udgivet i:Nat Commun
Main Authors: Makarov, Alex A., Zou, Juan, Houston, Douglas R., Spanos, Christos, Solovyova, Alexandra S., Cardenal-Peralta, Cristina, Rappsilber, Juri, Schirmer, Eric C.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6624373/
https://ncbi.nlm.nih.gov/pubmed/31296869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-11063-6
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