The β2-adrenergic receptor antagonist ICI-118,551 blocks the constitutively activated HIF signalling in hemangioblastomas from von Hippel-Lindau disease

One of the major consequences of the lack of a functional VHL protein in von Hippel-Lindau disease, a rare cancer, is the constitutive activation of the HIF pathway. This activation ends up in the generation of Central Nervous System (CNS) Hemangioblastomas among other tumours along the lifespan of...

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Udgivet i:Sci Rep
Main Authors: Cuesta, A. M., Albiñana, V., Gallardo-Vara, E., Recio-Poveda, L., de Rojas-P, I., de Las Heras, K. Villar Gómez, Aguirre, D. T., Botella, L. M.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6624208/
https://ncbi.nlm.nih.gov/pubmed/31296894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-46448-6
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