Natalizumab treatment reduces microglial activation in the white matter of the MS brain

OBJECTIVE: To evaluate whether natalizumab treatment reduces microglial activation in MS. METHODS: We measured microglial activation using the 18-kDa translocator protein (TSPO)-binding radioligand [(11)C]PK11195 and PET imaging in 10 patients with MS before and after 1 year treatment with natalizum...

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Pubblicato in:Neurol Neuroimmunol Neuroinflamm
Autori principali: Sucksdorff, Marcus, Tuisku, Jouni, Matilainen, Markus, Vuorimaa, Anna, Smith, Sarah, Keitilä, Joonas, Rokka, Johanna, Parkkola, Riitta, Nylund, Marjo, Rinne, Juha, Rissanen, Eero, Airas, Laura
Natura: Artigo
Lingua:Inglês
Pubblicazione: Lippincott Williams & Wilkins 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6624093/
https://ncbi.nlm.nih.gov/pubmed/31355310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/NXI.0000000000000574
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