A composition-dependent molecular clutch between T cell signaling condensates and actin

During T cell activation, biomolecular condensates form at the immunological synapse (IS) through multivalency-driven phase separation of LAT, Grb2, Sos1, SLP-76, Nck, and WASP. These condensates move radially at the IS, traversing successive radially-oriented and concentric actin networks. To under...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Ditlev, Jonathon A, Vega, Anthony R, Köster, Darius Vasco, Su, Xiaolei, Tani, Tomomi, Lakoduk, Ashley M, Vale, Ronald D, Mayor, Satyajit, Jaqaman, Khuloud, Rosen, Michael K
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2019
Assuntos:
Biochemistry and Chemical Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6624021/
https://ncbi.nlm.nih.gov/pubmed/31268421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.42695
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