Matrix Metalloproteinase-9 Contributes to Kindled Seizure Development in Pentylenetetrazole-Treated Mice by Converting Pro-BDNF to Mature BDNF in the Hippocampus

Recurrent seizure activity has been shown to induce a variety of permanent structural changes in the brain. Matrix metalloproteinases (MMPs) function to promote neuronal plasticity, primarily through cleavage of extracellular matrix proteins. Here, we investigated the role of MMP-9 in the developmen...

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Udgivet i:J Neurosci
Main Authors: Mizoguchi, Hiroyuki, Nakade, Junya, Tachibana, Masaki, Ibi, Daisuke, Someya, Eiichi, Koike, Hiroyuki, Kamei, Hiroyuki, Nabeshima, Toshitaka, Itohara, Shigeyoshi, Takuma, Kazuhiro, Sawada, Makoto, Sato, Jun, Yamada, Kiyofumi
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2011
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6623408/
https://ncbi.nlm.nih.gov/pubmed/21900575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3118-11.2011
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