Behavioral and In Vivo Electrophysiological Evidence for Presymptomatic Alteration of Prefrontostriatal Processing in the Transgenic Rat Model for Huntington Disease

Cognitive decline precedes motor symptoms in Huntington disease (HD). A transgenic rat model for HD carrying only 51 CAG repeats recapitulates the late-onset HD phenotype. Here, we assessed prefrontostriatal function in this model through both behavioral and electrophysiological assays. Behavioral e...

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Publicat a:J Neurosci
Autors principals: Höhn, Sophie, Dallérac, Glenn, Faure, Alexis, Urbach, Yvonne K., Nguyen, Huu Phuc, Riess, Olaf, von Hörsten, Stephan, Le Blanc, Pascale, Desvignes, Nathalie, El Massioui, Nicole, Brown, Bruce L., Doyère, Valerie
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2011
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6622938/
https://ncbi.nlm.nih.gov/pubmed/21677182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1238-11.2011
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