A New Concept: Aβ(1–42) Generates a Hyperfunctional Proteolytic NCX3 Fragment That Delays Caspase-12 Activation and Neuronal Death

Although the amyloid-β(1–42) (Aβ(1–42)) peptide involved in Alzheimer's disease is known to cause a dysregulation of intracellular Ca(2+) homeostasis, its molecular mechanisms still remain unclear. We report that the extracellular-dependent early increase (30 min) in intracellular calcium conce...

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Publicat a:J Neurosci
Autors principals: Pannaccione, Anna, Secondo, Agnese, Molinaro, Pasquale, D'Avanzo, Carla, Cantile, Maria, Esposito, Alba, Boscia, Francesca, Scorziello, Antonella, Sirabella, Rossana, Di Renzo, Gianfranco, Annunziato, Lucio
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2012
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6621392/
https://ncbi.nlm.nih.gov/pubmed/22855810
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.6429-11.2012
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