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Dendrimer-conjugated podophyllotoxin suppresses DENA-induced HCC progression by modulation of inflammatory and fibrogenic factors

Podophyllotoxin has been explored as an anticancer, antiviral, and antibacterial agent; however, its low water solubility and toxicity limit its use. In this study, the efficacy of a more soluble and less toxic polyamidoamine (PAMAM) dendrimer-conjugated podophyllotoxin (DPODO) was evaluated against...

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Detalles Bibliográficos
Publicado en:Toxicol Res (Camb)
Main Authors: Sharma, Supriya, Mehak, Chhimwal, Jyoti, Patial, Vikram, Sk, Ugir Hossain
Formato: Artigo
Idioma:Inglês
Publicado: Royal Society of Chemistry 2019
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6621132/
https://ncbi.nlm.nih.gov/pubmed/31367338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9tx00103d
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