Activation of the mTORC1/PGC-1 axis promotes mitochondrial biogenesis and induces cellular senescence in the lung epithelium

Cellular senescence is a biological process by which cells lose their capacity to proliferate yet remain metabolically active. Although originally considered a protective mechanism to limit the formation of cancer, it is now appreciated that cellular senescence also contributes to the development of...

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Veröffentlicht in:Am J Physiol Lung Cell Mol Physiol
Hauptverfasser: Summer, Ross, Shaghaghi, Hoora, Schriner, DeLeila, Roque, Willy, Sales, Dominic, Cuevas-Mora, Karina, Desai, Vilas, Bhushan, Alok, Ramirez, Maria I., Romero, Freddy
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2019
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6620667/
https://ncbi.nlm.nih.gov/pubmed/30892080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00244.2018
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