Interrogation of nonconserved human adipose lincRNAs identifies a regulatory role of linc-ADAL in adipocyte metabolism

Long intergenic noncoding RNAs (lincRNAs) have emerged as important modulators of cellular functions. Most lincRNAs are not conserved among mammals, raising the fundamental question of whether nonconserved adipose-expressed lincRNAs are functional. To address this, we performed deep RNA sequencing o...

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Pubblicato in:Sci Transl Med
Autori principali: Zhang, Xuan, Xue, Chenyi, Lin, Jennie, Ferguson, Jane F., Weiner, Amber, Liu, Wen, Han, Yumiao, Hinkle, Christine, Li, Wenjun, Jiang, Hongfeng, Gosai, Sager, Hachet, Melanie, Garcia, Benjamin A., Gregory, Brian D., Soccio, Raymond E., Hogenesch, John B., Seale, Patrick, Li, Mingyao, Reilly, Muredach P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6620026/
https://ncbi.nlm.nih.gov/pubmed/29925637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aar5987
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