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Cardiovascular effects of intravenous colforsin in normal and acute respiratory acidosis canine models: A dose-response study

In acidosis, catecholamines are attenuated, and higher doses are often required to improve cardiovascular function. Colforsin activates adenylate cyclase in cardiomyocytes without beta-adrenoceptor. Here, six beagles were administered colforsin or dobutamine four times during eucapnia (partial press...

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Bibliografiske detaljer
Udgivet i:PLoS One
Main Authors: Itami, Takaharu, Hanazono, Kiwamu, Oyama, Norihiko, Sano, Tadashi, Makita, Kohei, Yamashita, Kazuto
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6619603/
https://ncbi.nlm.nih.gov/pubmed/31291253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0213414
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