Neutralization of Inhibitory Molecule NG2 Improves Synaptic Transmission, Retrograde Transport, and Locomotor Function after Spinal Cord Injury in Adult Rats

NG2 belongs to the family of chondroitin sulfate proteoglycans that are upregulated after spinal cord injury (SCI) and are major inhibitory factors restricting the growth of fibers after SCI. Neutralization of NG2's inhibitory effect on axon growth by anti-NG2 monoclonal antibodies (NG2-Ab) has...

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Published in:J Neurosci
Main Authors: Petrosyan, Hayk A., Hunanyan, Arsen S., Alessi, Valentina, Schnell, Lisa, Levine, Joel, Arvanian, Victor L.
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2013
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6619302/
https://ncbi.nlm.nih.gov/pubmed/23447612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4702-12.2013
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