Sodium Channel Cleavage Is Associated with Aberrant Neuronal Activity and Cognitive Deficits in a Mouse Model of Alzheimer's Disease

BACE1 is the rate-limiting enzyme that cleaves amyloid precursor protein (APP) to produce the amyloid β peptides that accumulate in Alzheimer's disease (AD). BACE1, which is elevated in AD patients and APP transgenic mice, also cleaves the β2-subunit of voltage-gated sodium channels (Navβ2). Al...

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Published in:J Neurosci
Main Authors: Corbett, Brian F., Leiser, Steven C., Ling, Huai-Ping, Nagy, Reka, Breysse, Nathalie, Zhang, Xiaohong, Hazra, Anupam, Brown, Jon T., Randall, Andrew D., Wood, Andrew, Pangalos, Menelas N., Reinhart, Peter H., Chin, Jeannie
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2013
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6618875/
https://ncbi.nlm.nih.gov/pubmed/23595759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2325-12.2013
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