Empiric Methods to Account for Pre-analytical Variability in Digital Histopathology in Frontotemporal Lobar Degeneration

Digital pathology is increasingly prominent in neurodegenerative disease research, but variability in immunohistochemical staining intensity between staining batches prevents large-scale comparative studies. Here we provide a statistically rigorous method to account for staining batch effects in a l...

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Detalhes bibliográficos
Publicado no:Front Neurosci
Main Authors: Giannini, Lucia A. A., Xie, Sharon X., Peterson, Claire, Zhou, Cecilia, Lee, Edward B., Wolk, David A., Grossman, Murray, Trojanowski, John Q., McMillan, Corey T., Irwin, David J.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6616086/
https://ncbi.nlm.nih.gov/pubmed/31333403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2019.00682
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