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Evidence for distinct rate-limiting steps in the cleavage of alkenes by carotenoid cleavage dioxygenases

Carotenoid cleavage dioxygenases (CCDs) use a nonheme Fe(II) cofactor to split alkene bonds of carotenoid and stilbenoid substrates. The iron centers of CCDs are typically five-coordinate in their resting states, with solvent occupying an exchangeable site. The involvement of this iron-bound solvent...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Khadka, Nimesh, Farquhar, Erik R., Hill, Hannah E., Shi, Wuxian, von Lintig, Johannes, Kiser, Philip D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6615678/
https://ncbi.nlm.nih.gov/pubmed/31138651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.007535
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