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The Ca-loop in thymidylate kinase is critical for growth and contributes to pyrimidine drug sensitivity of Candida albicans

The yeast Candida albicans is the most prevalent opportunistic fungal pathogen in humans. Drug resistance among C. albicans isolates poses a common challenge, and overcoming this resistance represents an unmet need in managing this common pathogen. Here, we investigated CDC8, encoding thymidylate ki...

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Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Huang, Chang-Yu, Chen, Yee-Chun, Wu-Hsieh, Betty A., Fang, Jim-Min, Chang, Zee-Fen
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6615673/
https://ncbi.nlm.nih.gov/pubmed/31152062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006798
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