Fusaric acid-induced promoter methylation of DNA methyltransferases triggers DNA hypomethylation in human hepatocellular carcinoma (HepG2) cells

Fusaric acid (FA), a mycotoxin contaminant of maize, displays toxicity in plants and animals; however, its epigenetic mechanism is unknown. DNA methylation, an epigenetic modification that regulates gene expression, is mediated by DNA methyltransferases (DNMTs; DNMT1, DNMT3A, and DNMT3B) and demethy...

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Detalhes bibliográficos
Publicado no:Epigenetics
Main Authors: Ghazi, Terisha, Nagiah, Savania, Naidoo, Pragalathan, Chuturgoon, Anil A.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2019
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6615533/
https://ncbi.nlm.nih.gov/pubmed/31060424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15592294.2019.1615358
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