Amyloid-β-Induced Action Potential Desynchronization and Degradation of Hippocampal Gamma Oscillations Is Prevented by Interference with Peptide Conformation Change and Aggregation

The amyloid-β hypothesis of Alzheimer's Disease (AD) focuses on accumulation of amyloid-β peptide (Aβ) as the main culprit for the myriad physiological changes seen during development and progression of AD including desynchronization of neuronal action potentials, consequent development of aber...

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Vydáno v:J Neurosci
Hlavní autoři: Kurudenkandy, Firoz Roshan, Zilberter, Misha, Biverstål, Henrik, Presto, Jenny, Honcharenko, Dmytro, Strömberg, Roger, Johansson, Jan, Winblad, Bengt, Fisahn, André
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2014
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6615507/
https://ncbi.nlm.nih.gov/pubmed/25143621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1195-14.2014
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