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High glucose promotes annulus fibrosus cell apoptosis through activating the JNK and p38 MAPK pathways

Diabetes mellitus (DM) is an important risk factor of intervertebral disc degeneration. A high glucose niche-mediated disc cell apoptosis is an implicate causative factor for the spine degenerative diseases related with DM. However, the effects of a high glucose niche on disc annulus fibrosus (AF) c...

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Detalhes bibliográficos
Publicado no:Biosci Rep
Main Authors: Shan, Lizhen, Yang, Di, Zhu, Danjie, Feng, Fabo, Li, Xiaolin
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6614572/
https://ncbi.nlm.nih.gov/pubmed/31221817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BSR20190853
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