Inhibition of activin-like kinase 4/5 attenuates cancer cachexia associated muscle wasting

Cancer mediated activation of the ActRIIB-ALK4/5 heterodimer by myostatin is strongly associated with muscle wasting. We investigated in vitro and in vivo the efficacy of ALK4/5 receptor blockers SB431542 and GW788388 in preventing muscle wasting, and explored synergy with IGF-I analogue LONG R3 (LR...

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Bibliografski detalji
Izdano u:Sci Rep
Glavni autori: Levolger, S., Wiemer, E. A. C., van Vugt, J. L. A., Huisman, S. A., van Vledder, M. G., van Damme-van Engel, S., Ambagtsheer, G., IJzermans, J. N. M., de Bruin, R. W. F.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2019
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6614551/
https://ncbi.nlm.nih.gov/pubmed/31285507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-46178-9
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