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Oxazole-Benzenesulfonamide Derivatives Inhibit HIV-1 Reverse Transcriptase Interaction with Cellular eEF1A and Reduce Viral Replication

HIV-1 replication requires direct interaction between HIV-1 reverse transcriptase (RT) and cellular eukaryotic translation elongation factor 1A (eEF1A). Our previous work showed that disrupting this interaction inhibited HIV-1 uncoating, reverse transcription, and replication, indicating its potenti...

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Bibliografiske detaljer
Udgivet i:J Virol
Main Authors: Rawle, Daniel J., Li, Dongsheng, Wu, Zhonglan, Wang, Lu, Choong, Marcus, Lor, Mary, Reid, Robert C., Fairlie, David P., Harris, Jonathan, Tachedjian, Gilda, Poulsen, Sally-Ann, Harrich, David
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2019
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6613760/
https://ncbi.nlm.nih.gov/pubmed/30918071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00239-19
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